The ShcA adapter protein transmits activating signals downstream of receptor and cytoplasmic tyrosine kinases through the establishment of phosphotyrosine-dependent complexes. In this regard, ShcA ...

SH2 domains bind phosphotyrosine residues within the correct context of adjacent carboxy-terminal amino acids. SH2 domains contain a 7-stranded b-meander, and bind with their peptide ligands that lie ...

Prof. You-Me Kim and her student Dajung Jung at Pohang University of Science and Technology (POSTECH), in collaboration with Prof. Wonhwa Cho's group at the University of Illinois at Chicago, have ...

SAN DIEGO, Nov. 15, 2021 (GLOBE NEWSWIRE) -- Recludix Pharma, a leader in platform approaches to discover inhibitors of challenging cancer and inflammatory disease targets, today announced its launch ...

Majority of human Src homology 2 (SH2) domains not only bind to proteins, but also interact with membrane lipids with high affinity and specificity. The SH2 domain-containing proteins play important ...

SAN DIEGO, May 07, 2025 (GLOBE NEWSWIRE) -- Recludix Pharma, a leader in the discovery of inhibitors of challenging targets for inflammatory disease, today announced data will be presented at the ...

New research describes a large set of interactions (interactome) which maps the range of phosphotyrosine (pTyr)-dependent interactions with SH2 domains underlying insulin (Ins), insulin-like growth ...

New research published in BioMed Central's open access journal Cell Communication and Signaling describes a large set of interactions (interactome) which maps the range of phosphotyrosine ...

-- Bruton's tyrosine kinase (BTK) SH2 inhibitor reduced skin inflammation in a clinically-relevant model of chronic spontaneous urticaria (CSU) --BTK inhibition through the SH2 domain results in ...

Receptor tyrosine kinases (RTKs) regulate many critical biological processes such as cell growth, differentiation, and survival through the recruitment of intracellular signaling molecules. The ...