News, features, and commentary about cancer-related issues ...

在后面的 2008 年至 2015 年间，至少有 67 名来自 8 个国家中 46 个家庭的儿童，是使用了 Bill 的精子孕育的，截至目前，已有 10 名儿童已被诊断出患有不同类型的癌症，包括白血病和非霍奇金淋巴瘤。[1] ...

A genetic mutation that carries a 90% cancer risk has been passed on by an unwitting sperm donor to dozens of children, a ...

1979年科学家发现了p53蛋白，自此p53蛋白一直活跃于生物医学领域，尤其在肿瘤研究领域几乎无人不知。 人类p53蛋白由抑癌基因TP53编码，很多研究发现，TP53的失活突变与癌症的侵袭性和难治性息息相关[1，2]。 大量研究表明，p53失活是基因组混乱的诱因，并且TP53 ...

自从免疫治疗出现后，改写了多个癌种的治疗指南，肿瘤患者的生存期也大大延长。在非小细胞肺癌（NSCLC）治疗领域，PD-1/PD-L1 单抗改善了驱动基因阴性 NSCLC 患者的预后。 免疫治疗的临床应用离不开生物标志物的指导。PD-1/PD-L1 表达、TMB、MSI-H/dMMR 肿瘤患者均可 ...

A sperm donor, who is an asymptomatic carrier of a genetic mutation increasing the risk of cancer, was used to conceive ...

Because only part of the man's sperm carried the mutation, only the second round of genetic testing revealed the problem. By ...

A sperm donor with a rare genetic mutation linked to an increased risk of developing cancer fathered at least 197 children across Europe, some of whom have already died from the disease, according to ...

Carrick Therapeutics Inc., an oncology-focused biopharmaceutical company discovering and developing highly differentiated therapies, today announced positive results from the Phase 2 SUMIT-BC clinical ...

European fertility clinics used cancer-causing sperm for 17 years, prompting urgent calls for genetic screening reforms and ...

p53 mutants are among the most common protein variants expressed in cancer cells. Classifying TP53 status in human cancer as ‘inactivated’ or ‘loss-of-function’ is misleading. Many mutant p53 variants ...