皮肤黑色素瘤（SKCM）中COMMD4通过调控PI3K-AKT通路和上皮-间质转化促进肿瘤进展，三聚氰胺可有效抑制其作用。 摘要 皮肤黑色素瘤（SKCM）是全球最具侵袭性的皮肤恶性肿瘤，其分子驱动机制仍知之甚少。尽管铜代谢相关蛋白家族MURR1结构域（COMMD）与肿瘤发生 ...

Myriad of Groups Are Working on the Latest Hot Target and Most Are Optimistic About Its Potential Although the term “signal transduction” was coined back in 1972, cell-signaling switches have only ...

March 9, 2011, 7:45 AM EST / Source: GlobeNewswire INDIANAPOLIS, March 9, 2011 (GLOBE NEWSWIRE) -- Semafore Pharmaceuticals announced today that preclinical data in B-cell malignancies for the company ...

INDIANAPOLIS, April 5, 2011 (GLOBE NEWSWIRE) -- Semafore Pharmaceuticals today announced encouraging preclinical results for its lead product candidate, SF1126, in certain B-cell malignancies. The ...

Merkel Cell Carcinoma (MCC) is a highly aggressive cancer of the skin. It is characterized by a high recurrence rate and a very poor five-year prognosis. Drugs targeting the programmed cell death ...