2025 年 9 月 5 日，国际顶尖学术期刊 Nature 在其官网报道了一则新闻——世界首批 CRISPR 基因编辑马诞生。 这些马看起来可能与普通马无异，但它们的基因组却有着极不寻常之处。它们是第一批通过 CRISPR-Cas9 技术进行基因编辑的马，它们肌肉更强、速度更快。

本综述系统探讨了CRISPR 2.0技术（碱基编辑/先导编辑）在改造T细胞疗法中的突破性应用。通过精准基因编辑可增强T细胞功能 ...

本综述系统探讨了CRISPR-Cas系统在液体活检领域革命性应用。文章详述了如何将Cas9（基因编辑工具）、Cas12a（DNA检测）和Cas13a（RNA检测）与适配体识别、纳米材料富集及杂交链式反应（HCR）、滚环扩增（RCA）等信号放大技术融合，实现对循环肿瘤细胞（CTCs）和 ...

The practice of genetic modification is as old as humanity. For thousands of years, humans have bred crops, livestock and even pets that possess desirable traits. This selective process, which alters ...

Northwestern scientists have developed a new nanostructure that supercharges CRISPR’s ability to safely and efficiently enter cells, potentially unlocking its full power to treat genetic diseases. By ...

When the genome-editing tool CRISPR is thought of as a potential medicine, the targets that first come to mind are diseases like sickle cell or other conditions caused by particular mutations. Use ...

该研究将 CRISPR 激活（CRISPRa）技术应用于 SCN2A 单倍体不足的治疗，在相当于人类 10 岁的青春期小鼠模型中，成功恢复了其大脑中 SCN2A 水平，逆转了神经发育障碍。 大多数单基因诊断的神经发育障碍通过单倍体不足（haploinsufficiency）机制致病，即一个基因的 ...

CRISPR has the power to correct genetic mutations, but current delivery methods are either unsafe or inefficient, keeping the technology from reaching its full medical potential. With the power to ...

It was only 11 years ago that scientists Jennifer Doudna and Emmanuelle Charpentier first described a new way to edit genes, called CRISPR, in a scientific paper. The discovery is so game-changing ...